Cyclic Peptides: Promising Scaffolds for Biopharmaceuticals
نویسندگان
چکیده
منابع مشابه
Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds.
Fragments from the extracellular matrix proteins laminin and osteopontin and a sequence from VEGF have potent proangiogenic activity despite their small size (< 10 residues). However, these linear peptides have limited potential as drug candidates for therapeutic angiogenesis because of their poor stability. In the present study, we show that the therapeutic potential of these peptides can be s...
متن کاملSpatial Screening of Lectin Ligands. Cyclic Peptides as Scaffolds for Multivalent Presentation of Carbohydrates
Introduction Carbohydrate-lectin interactions are the basis of numerous biologically important recognition processes [1]. Examples include the initiation of the inflammatory response, bacterial and viral pathogenesis, fertilization, and even protein folding. High-affinity lectin ligands are of considerable medicinal interest in the diagnosis, therapy, and prevention of conditions associated wit...
متن کاملOn-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds
Backbone N-methylation is common among peptide natural products and has a substantial impact on both the physical properties and the conformational states of cyclic peptides. However, the specific impact of N-methylation on passive membrane diffusion in cyclic peptides has not been investigated systematically. Here we report a method for the selective, on-resin N-methylation of cyclic peptides ...
متن کاملCell Penetrating Peptides in the Delivery of Biopharmaceuticals
The cell membrane is a highly selective barrier. This limits the cellular uptake of molecules including DNA, oligonucleotides, peptides and proteins used as therapeutic agents. Different approaches have been employed to increase the membrane permeability and intracellular delivery of these therapeutic molecules. One such approach is the use of Cell Penetrating Peptides (CPPs). CPPs represent a ...
متن کاملChemical synthesis, backbone cyclization and oxidative folding of cystine-knot peptides: promising scaffolds for applications in drug design.
Cystine-knot peptides display exceptional structural, thermal, and biological stability. Their eponymous motif consists of six cysteine residues that form three disulfide bonds, resulting in a notably rigid structural core. Since they highly tolerate either rational or combinatorial changes in their primary structure, cystine knots are considered to be promising frameworks for the development o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genes
سال: 2018
ISSN: 2073-4425
DOI: 10.3390/genes9110557